Robotics for Comprehensive Physiological Pharmaceutical Performance
There are two open positions for postdoctoral scientists in a collaborative project Janssen – KU Leuven – Universiteit Gent. A description can be found here.
Understanding the in vivo gastrointestinal behavior of oral formulations is instrumental for their efficient and successful development. While biopharmaceutical assessments are needed to create this understanding and predict the in vivo behavior, currently available tools are resource intensive and lack some of the physiological parameters and outputs that are critical to allow a comprehensive assessment. Moreover, the focus of available tools is mainly directed towards immediate release formulation platforms typically for small molecules while the need for local or controlled release delivery platforms is increasing rapidly.
Critical gaps will be addressed to enable biopharmaceutical support on multiple formulation platforms. The potential of emerging high throughput technologies will be investigated to allow systematic and more comprehensive biopharmaceutical assessments with minimal compound/formulation requirements starting at the drug discovery stage and progressing towards clinical development. In parallel, a customized in silico platform will be developed allowing fast and straight-forward in vitro data translation and interpretation.